Core Existence: Monomer: Ensures that at least 21 residues are buried in the core of the monomer unit.
Core Existence: Complex: Ensures that at least 72 residues are buried in the core of the entire complex (including the interface between monomer units). The threshold of "buriedness" between core and surface residues is more stringent than usual, so residues may have to be "extra buried" to be counted toward the core of the protein complex.
HBond Network: Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 75% satisfied (i.e. 75% of all polar atoms in a network must make a hydrogen bond).
SS Design: Prohibits all CYS residues. Prohibits GLY, ALA residues in sheets and helices.
It takes a solid 14 seconds to roll a helix, something that should be an instantaneous job. Other actions like freezing do not work as the system is too unresponsive. I have a current generation system.
For freeezing, I use the following recipe:
I did this on my stream today, I just got too tired of waiting 3 seconds every time I chucked a building block into my monomer using Blueprint mode. I'm running an i7-7700K (4.20 GHz) with an SSD and graphics card setup, too. I just didn't have it in me to even finish a monomer.
It is a strangely slow puzzle; very hard to work on.
It would be good if we knew the max score on the filter.
The max total filter bonus is +8070, broken down as:
Core Existence Monomer: +2260 max
Core Existence Complex: +3760 max
SS Design: +500 max
Hydrogen Bond Network: +1600 max
The h-bond bonus is 200 points per interface h-bond, up to a maximum of 8.
Thanks to reefyrob for sharing a solution with max bonus, makes determining this info pretty easy. He has 10 bonds in one network, but only six are interface bonds. The network bonds to one sidechain, then continues through a backbone oxygen atom to another sidechain.
Extremely slow and heavy: could you give us some more time ?