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1564: Find the Hydrogen Bond Networks!
Status: Closed


Name: 1564: Find the Hydrogen Bond Networks!
Status: Closed
Created: 08/20/2018
Points: 100
Expired: 08/27/2018 - 23:00
Difficulty: Intermediate
Description: This puzzle is a little different from other H-bond network design puzzles in Foldit. This protein is another dimer (i.e. two chains fold up and bind each other) that was designed in the Baker Lab. The original design has three different H-bond networks that span the interface between the two chains, but we've mutated the network residues to alanine. In order to solve this puzzle, Foldit players will have to mutate the alanine residues back into residues that can form satisfied H-bond networks. The protein backbone is fixed in this puzzle, and only the alanine residues can be mutated. We want to know how well Foldit players are able to find networks using the tools currently in Foldit.
Categories: Design, Overall

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bkoep's picture
User offline. Last seen 36 min 23 sec ago. Offline
Joined: 11/15/2012
Groups: None

Core Existence: Complex: Ensures that at least 48 residues are buried in the core of the entire complex (including the interface between monomer units). In this puzzle, since the backbone is fixed, the Core Existence objective will not affect the score.

HBond Network: Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 75% satisfied (i.e. 75% of all polar atoms in a network must make a hydrogen bond).

Joined: 10/30/2012
Groups: Beta Folders
limit on the number of bonds

have shared 2 try's, under the headings save for loci 1 and 2

there are seeming scoring anomalies.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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