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1563: Extra Large Monomer Design
Status: Closed


Name: 1563: Extra Large Monomer Design
Status: Closed
Created: 08/16/2018
Points: 100
Expired: 08/23/2018 - 23:00
Difficulty: Intermediate
Description: This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 32 points per residue. We've recently amended the old system of Conditions, or Filters. These have been rebranded as Objectives, and are reformulated so that they typically increase the base Foldit score (although it is still possible to receive a penalty from an Objective, in some cases). Ultimately, the function of each Objective is the same as it always has been (e.g. adding a residue still subtracts 32 points from the Residue Count objective), but we hope that the Objectives will be more encouraging than the old Filters—especially for new players who are still getting the hang of things. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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bkoep's picture
User offline. Last seen 18 hours 2 min ago. Offline
Joined: 11/15/2012
Groups: None

Interaction Energy: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Prohibits all CYS residues. Prohibits GLY, ALA residues in sheets. Prohibits GLY, ALA, SER, THR in helices.

Residue Count: Normalizes for extra residues inserted beyond the starting 95, at a cost of 32 points per residue. Players may use up to 120 residues in total.

LociOiling's picture
User offline. Last seen 5 hours 16 min ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
not seeing a residue count penalty

The Residue Count filter doesn't seem to be making a deduction, even with the maximum of 25 additional residues.

bkoep's picture
User offline. Last seen 18 hours 2 min ago. Offline
Joined: 11/15/2012
Groups: None
That's correct

Sorry if this wasn't clear in the puzzle description!

The Residue Count objective should not give any penalties in this puzzle. With the starting count of 95 residues, the objective should give a bonus of +800 points. With the maximum addition of 25 residues, the objective should give no bonus (zero points).

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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