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1552: Find the Hydrogen Bond Networks!
Status: Closed


Name: 1552: Find the Hydrogen Bond Networks!
Status: Closed
Created: 07/21/2018
Points: 100
Expired: 07/28/2018 - 23:00
Difficulty: Intermediate
Description: This puzzle is a little different from other prediction puzzles in Foldit. This protein is a dimer (i.e. two chains fold up and bind each other) that was designed in the Baker Lab. The design has two identical H-bond networks that span the interface between the two chains. In order to solve this puzzle, Foldit players will have to fold each of the two chains, bring them together, and arrange the interface to form the two H-bond networks. The secondary structure of the designed protein is marked on the starting structure. See if you can fold this protein and find the H-bond networks!
Categories: Overall, Prediction

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bkoep's picture
User offline. Last seen 1 day 15 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Core Existence: Complex: Ensures that at least 48 residues are buried in the core of the entire complex (including the interface between monomer units).

HBond Network: Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 75% satisfied (i.e. 75% of all polar atoms in a network must make a hydrogen bond).

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons