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1533: Symmetric Trimer Design: Hydrogen Bond Networks
Status: Closed

Summary

Name: 1533: Symmetric Trimer Design: Hydrogen Bond Networks
Status: Closed
Created: 06/12/2018
Points: 100
Expired: 06/19/2018 - 23:00
Difficulty: Intermediate
Description: This symmetric design puzzle has C3 symmetry, with three symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the three chains. We've doubled the H-bond network bonus, but we'd like players to focus on building networks deep in the core of the protein complex. There a couple other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

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1Anthropic Dreams18,395100
2Beta Folders18,16377
3Contenders17,95058
4Gargleblasters17,94043
5Go Science17,86031

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Comments

bkoep's picture
User offline. Last seen 2 hours 36 min ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Core Existence: Monomer: Ensures that at least 24 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 72 residues are buried in the core of the entire complex (including the interface between monomer units). The threshold of "buriedness" between core and surface residues is more stringent than usual, so residues may have to be "extra buried" to be counted toward the core of the protein complex.

HBond Network: Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 75% satisfied (i.e. 75% of all polar atoms in a network must make a hydrogen bond).

Joined: 09/24/2012
Groups: Go Science
Crashing on hand fold, linux and windows

Crashing on running Ideal SS on latest segments (helix then one segment). See crash report in feedback.

Joined: 10/30/2012
Groups: Beta Folders
unplayable

diapering without a trace

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons