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1524: Symmetric Dimer Design: Hydrogen Bond Networks
Status: Closed

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bkoep's picture
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Joined: 11/15/2012
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Core Existence: Monomer: Ensures that at least 25 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 60 residues are buried in the core of the entire complex (including the interface between monomer units).

HBond Network: Rewards networks comprising at least three hydrogen bonds. Up to four hydrogen bonds may span the interface between chains. Networks must at least 75% satisfied (i.e. 75% of all polar atoms in a network must make a hydrogen bond).

Joined: 05/19/2017
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Video of network establishment

As of yet I haven't figured out any way to intuitively design networks from scratch quite yet. Reading about it, it seems straightforward on paper but kind of harder in practice. Has anyone made any videos on good strategies for these H-bond network puzzles or commentary on the process of building one?

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons