1519: HIV Protease Inhibitor Small Molecule Design: Round 2
|Name:||1519: HIV Protease Inhibitor Small Molecule Design: Round 2|
|Expired:||05/16/2018 - 23:00|
|Description:||Note: Due to player reports of persistent crashing, this puzzle is now worth zero points, so players may skip this puzzle without any effect on their rankings. However, if players would like to continue playing the puzzle, we will still analyze the puzzle solutions. And of course, we appreciate all of the detailed feedback about the puzzle!
The goal of this puzzle is to change the chemical structure of the ligand in the center of the protein to find better inhibitors of HIV protease. It's less about changing the protein to fit the ligand, and more about changing the ligand to fit the protein. Use the Ligand Design tool in the selection interface (or the "Ligand Design" mode in the original interface) to alter the chemical identity of the inhibitor.
See this previous blog post for more information on small molecule design, and Puzzle 1432 for the previous round. In contrast with the previous round, we're starting with a smaller starting molecule and are running without a similarity filter.
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