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1515: Medium Monomer Design
Status: Closed

Summary

Name: 1515: Medium Monomer Design
Status: Closed
Created: 04/29/2018
Points: 0
Expired: 05/08/2018 - 23:00
Difficulty: Intermediate
Description: Note: This puzzle was closed early due to an erroneous Residue Count Filter, and reposted as Puzzle 1515b. Players may load their work from this puzzle into the reposted puzzle.

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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Comments

bkoep's picture
User offline. Last seen 3 days 15 hours ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 75, at a cost of 32 points per residue. Players may use up to 90 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

LociOiling's picture
User offline. Last seen 59 min 54 sec ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
penalty for more than 65 residues....

The puzzle starts with 75 residues, but it also starts with a residue count penalty of -320 points.

You cut this puzzle down to 65 residues if desired, but it can also be expanded to 90 residues as stated.

bkoep's picture
User offline. Last seen 3 days 15 hours ago. Offline
Joined: 11/15/2012
Groups: None
Bad Residue Count Filter

Sorry! There was a mistake in the Residue Count Filter. This has been corrected in Puzzle 1515b.

Joined: 05/02/2018
Groups: None
sience

i love puzzles4

Joined: 06/24/2008
Groups: Void Crushers
Strange seg limit

It is really a 65 seg puzzle. So should we cut back to 65??

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons