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1509: Small Monomer Design
Status: Closed
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Summary
| Name: |
1509: Small Monomer Design |
| Status: |
Closed |
| Created: |
04/17/2018 |
| Points: |
100 |
| Expired: |
04/24/2018 - 23:00 |
| Difficulty: |
Intermediate |
| Description: |
This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions! |
| Categories: | Design, Overall |
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| Soloists | |
| Evolvers | |
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| NinjaGreg 23 23 | 1712: Revisitin...xin | 11,734 | | Waya 6 8 | 1713: IL-7R Bin...d 5 | 11,590 | | silent gene 7 6 | 1714: Symmetric...ues | 22,982 | | jobo0502 76 24 | 1715: IL-7R Bin...d 6 | 11,503 | | ComputerMage 76 618 | Beginner Puzzle...ign | 10,358 | | kevin ever... 76 546 | Beginner Puzzle...yle | 8,219 | | Dj-P 76 281 | Beginner Puzzle...zle | 9,082 | | Dj-P 76 281 | Beginner Puzzle...nis | 9,958 | | Franco1947 76 1437 | Beginner Puzzle...ity | 15,963 | | Merf 76 54 | Beginner Puzzle...ign | 13,671 |
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| NinjaGreg 23 23 | 1712: Revisitin...xin | 11,734 | | Waya 6 8 | 1713: IL-7R Bin...d 5 | 11,590 | | silent gene 7 6 | 1714: Symmetric...ues | 22,982 | | jobo0502 76 24 | 1715: IL-7R Bin...d 6 | 11,503 | | ComputerMage 76 618 | Beginner Puzzle...ign | 10,358 | | kevin ever... 76 546 | Beginner Puzzle...yle | 8,219 | | Dj-P 76 281 | Beginner Puzzle...zle | 9,082 | | Dj-P 76 281 | Beginner Puzzle...nis | 9,958 | | Franco1947 76 1437 | Beginner Puzzle...ity | 15,963 | | Merf 76 54 | Beginner Puzzle...ign | 13,671 | |
| Go Science | 1712: Revisitin...xin | 11,734 | | Anthropic Dreams | 1713: IL-7R Bin...d 5 | 11,592 | | Go Science | 1714: Symmetric...ues | 22,982 | | L'Alliance Fran...one | 1715: IL-7R Bin...d 6 | 11,503 | | Russian team | Beginner Puzzle...ign | 10,358 | | Go Science | Beginner Puzzle...yle | 6,713 | | Go Science | Beginner Puzzle...zle | 9,082 | | Go Science | Beginner Puzzle...nis | 9,958 | | Go Science | Beginner Puzzle...ity | 15,578 | | Go Science | Beginner Puzzle...ign | 13,109 | |
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Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.
SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.
Residue Count: Penalizes extra residues inserted beyond the starting 65, at a cost of 32 points per residue. Players may use up to 75 residues in total.