1503: Y1 Receptor - Dock the ligand!
|Name:||1503: Y1 Receptor - Dock the ligand!|
|Expired:||04/09/2018 - 23:00|
|Description:||This is a ligand docking puzzle. Instead of changing the protein, we'd like you to focus on finding the best position and interactions for the ligand. (The residue in the middle of the alpha helices, currently making a number of clashes.)
This is a follow-up puzzle of 1441 and 1446. Like 1446, we're asking you to place a known binder to the human Y1 neuropeptide receptor into its binding site. Like 1446, this is ligand is BIBP-3226. In this puzzle, though, we're giving you a different protein structure.
We think the backbone of the binding site of this model is pretty close to the actual structure, so we're fixing the backbone. Focus on placing the ligand and optimizing the interactions of the ligand with the side-chains.
Need this puzzle? Log in to download.