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1500: Aflatoxin Challenge: Round 6 with Insertions
Status: Closed


Name: 1500: Aflatoxin Challenge: Round 6 with Insertions
Status: Closed
Created: 03/21/2018
Points: 100
Expired: 04/04/2018 - 23:00
Difficulty: Intermediate
Description: The aflatoxin puzzles are back! This puzzle is very similar to Puzzle 1455: Aflatoxin Challenge: Round 4, but parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details. Unfortunately, due to the scaffold trimming and the recent Foldit update, players will not be able to load solutions from Puzzle 1455.

Aflatoxins are a class of poisonous compounds that contaminate a significant portion of the global food supply. In this puzzle, players are challenged to redesign an enzyme that could break down aflatoxin molecules. The majority of the protein is frozen, with the aflatoxin ligand fixed in a binding pocket. Surrounding the binding pocket are a number of loops that might be redesigned without affecting the folding stability of the protein. In these loops, players may manipulate the protein backbone, insert additional residues, and mutate the residue sidechains. Redesign the loops of this protein to better bind the aflatoxin ligand!

This is the sixth puzzle of our Aflatoxin Challenge, sponsored by Mars Inc. and Thermo Fisher Scientific. Promising designs will be tested by the Siegel Lab at UC Davis. By participating in the challenge/game, the players agree that all player designs will be available permanently in the public domain, and the players will not seek intellectual property protection over the designs created as part of the challenge/game.
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toshiue's picture
User offline. Last seen 3 days 5 hours ago. Offline
Joined: 01/31/2016
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Anyone else unable to load any shares?

Can't load any share (1500) on any client on any machine. Is anyone else having load problems? (Posted on group and veterans but no answers.)

spvincent's picture
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Joined: 12/07/2007
Groups: Contenders
It took some time but

It took some time but eventually uploaded.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons