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1493: Primitive 70 Residue Monomer Design: CoreExists
Status: Closed


Name: 1493: Primitive 70 Residue Monomer Design: CoreExists
Status: Closed
Created: 03/08/2018
Points: 100
Expired: 03/13/2018 - 18:00
Difficulty: Intermediate
Description: This is another "primitive" style puzzle, in which we've disabled most of the filters normally used for Foldit protein design. The only filter in this puzzle is the CoreExists filter. Foldit has changed a great deal since we ran the first Foldit design puzzle, back in August of 2009, and the results of recent design puzzles have shown that Foldit players are now perfectly capable of designing well-folded, stable proteins. We'd like to write up a paper about these results, and it will be important to have a clear picture of what happens without those special tools and filters now used for protein design. For this puzzle, we're asking Foldit players to forget everything you've learned about protein design! This puzzle uses only a basic Rosetta scoring function, and we do not expect top-scoring designs to be realistic. But we're very curious whether Foldit players will find the same solutions as back in 2009. What is the best-scoring structure you can fold, with only the CoreExists filter?

Note that this puzzle will not be active for a full week, but will close early on March 13 to accommodate a planned Foldit software update.
Categories: Design, Overall

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons