1482: Medium Monomer Design

Summary

Name:

Status:

Closed

Created:

02/09/2018

Points:

100

Expired:

02/16/2018 - 23:00

Difficulty:

Intermediate

Description:

This puzzle challenges players to design a single-chain protein with 75-90 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Categories:

Design, Overall

Rank

Group

Score

Points

7,925

7,856

7,625

3,219

Rank

Player

Group

Score

Points

10,190

9,932

9,775

9,365

Rank

Player

Group

Score

Points

10,005

9,982

9,972

9,971

retiredmichael 45 1438

Beta Folders

9,955

Fri, 02/09/2018 - 21:38

#201

bkoep 45 251

Offline

Joined: 11/15/2012

Groups: Foldit Staff

Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85 70. Players may use up to ~~105~~ 90 residues in total.

Sat, 02/10/2018 - 00:00

#202

NinjaGreg 37 14

Offline

Joined: 05/21/2010

Groups: Go Science

Something wrong with the filters?

It shows I have 75 residues, and it says it's 5 over the limit of 70. I haven't added any so what you've said above about starting with 85 is incorrect, also.