puzzle picture
Beginner Puzzle (<150): Symmetry Design
Status: Closed


Name: Beginner Puzzle (<150): Symmetry Design
Status: Closed
Created: 01/27/2014
Points: 100
Expired: 03/15/2018 - 23:00
Difficulty: Beginner
Description: This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.


If you are new to Foldit, here are detailed instructions to get you started:

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :
- try all puzzles not only "Beginners" ones,
- fold first the ones you like the most,
- try it by yourself to understand what works and what doesn't,
- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:
- Lonely Sheets,
- Lock and Lower,
- Rebuild,
- Structure and Rebuild,
- Movin' Along,
- Control over Clashing,
- Intro to Design,
- Swappin' Sidechains,
- Mass Mutate,
- Insertion and Deletion

before starting this puzzle.

Categories: Beginner

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SaraL's picture
User offline. Last seen 1 year 22 weeks ago. Offline
Joined: 09/20/2011
Groups: Gargleblasters
Instant Crash

Testing out the symmetry puzzle - I did something simple. I made one end a helix and the other end a sheet. Did Ideal SS on the helix, froze it, then went to pull the sheet into position - the client crashed instantly.

LociOiling's picture
User offline. Last seen 1 hour 58 min ago. Offline
Joined: 12/27/2012
May be crashy...

Symmetry puzzles haven't been working right in quite a while.

I tried this one, and got a crash on Windows when I followed the general steps SaraL listed. Pulling on the sheet seemed to cause the crash.

I got a little further using cutpoints, but hit a crash again a few minutes later while running a recipe.

Obviously some people are either lucky or very persistent and are able to make progress despite the crashes.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons