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1476: Primitive 70 Residue Monomer Design
Status: Closed


Name: 1476: Primitive 70 Residue Monomer Design
Status: Closed
Created: 01/26/2018
Points: 100
Expired: 02/02/2018 - 23:00
Difficulty: Intermediate
Description: Like Puzzle 1473, this puzzle lacks the regular design filters, although many of the design tools have been restored (i.e. Remix, Rama Map, Blueprint Panel). Foldit has changed a great deal since we ran the first Foldit design puzzle, back in August of 2009, and the results of recent design puzzles have shown that Foldit players are now perfectly capable of designing well-folded, stable proteins. We'd like to write up a paper about these results, and it will be important to have a clear picture of what happens without those special tools and filters now used for protein design. We're asking Foldit players to forget everything you've learned about protein design! This puzzle uses only a basic Rosetta scoring function, and we do not expect top-scoring designs to be realistic. But we're very curious whether Foldit players will find the same solutions as back in 2009. What is the best-scoring structure you can come up with without the design filters?
Categories: Design, Overall

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Joined: 09/21/2011
Groups: Void Crushers
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons