puzzle picture
1470: Small Monomer Design
Status: Active

Summary

Name: 1470: Small Monomer Design
Status: Active
Created: 01/12/2018
Points: 100
Expires: 01/19/2018 - 23:00
Difficulty: Intermediate
Description: This puzzle challenges players to design a single-chain protein with 65-75 residues. In this design puzzle, we've deactivated the Ideal Loops filter, so players have more flexibility to design their own high-scoring loops! The starting structure has 65 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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Comments

bkoep's picture
User offline. Last seen 18 min 58 sec ago. Offline
Joined: 11/15/2012
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Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 65. Players may use up to 75 residues in total.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons