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1439: Classroom Puzzle: Chaperone Folding
Status: Closed

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LociOiling's picture
User offline. Last seen 13 hours 1 min ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
not centered at the start

When this puzzle starts, you may see only the locked part, segments 109 to 301, on-screen. For me, the designable part, 1 to 108 was off-screen on the top right.

The "q" shortcut or the home key on windows centers the protein in the window. Shift-drag on the background and zoom the protein in or out.

LociOiling's picture
User offline. Last seen 13 hours 1 min ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
yep, 301 segments

Even though a lot of them are locked, 301 segments is on the ginnormous size for a Foldit puzzle.

LociOiling's picture
User offline. Last seen 13 hours 1 min ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
still playable...

I'm able to play this puzzle on my old laptop, with two logical processors ("cores") and 2 GB memory. Unlike most puzzles, this one uses significantly more than one logical processor when running a recipe with the window minimized. On the two-processor system, just one Foldit client is using 70% or more of CPU, using up most of one processor and much of the other one.

See also: http://fold.it/portal/node/990207

Joined: 05/19/2017
Groups: None
foldit.ppt has stopped responding

Snarky PowerPoint presentation framerate comments aside I really wish I could have my GPU pick up some of the slack for this big boy puzzle.

Joined: 09/24/2012
Groups: Go Science
In player's words?

Personally, I don't understand what we are suppose to look for, and what the students are suppose to learn from the papers.
As I understand, we have a freezed (part of) solved protein and another (solved) one that is supposed to glue to the first one (with sidechain bonds or so). We could try to make as much bonds as possible, or not to glue but to try to optimize the proteins separately.
Is that correct?

The papers then confused me. If I understand well, the freezed one is supposed to change the ideal shape of the second one. I don't know if a part of the second one has to go inside of a tunel in the first one.

SaraL's picture
User offline. Last seen 1 year 30 weeks ago. Offline
Joined: 09/20/2011
Groups: Gargleblasters
Banding

Any recipe with bands will attempt to bind the foldable protein to the frozen one. Is this useless or intentional?

Would it be feasible to wrap the foldable protein around the frozen protein in order to create bonds?

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons