1411: Unsolved De-novo Freestyle 113 Status: Closed

# Soloists

RankPlayerGroupScorePoints
101spritz1992 60 2065  8,8221
102dizzywings 60 2065 Gargleblasters8,7941
103RhialtoAhn 60 2065  8,7691
104toshiue 12 79 Go Science8,7261
105momadoc 60 661  8,7091
106ppp6 60 2065  8,6731
107TePie 60 2065  8,6421
108rtkitters 60 2065  8,6121
109Arne Heessels 60 204  8,5911
110ncameron 60 2065  8,5781
111MicElephant 30 19  8,5531
112ViJay7019 60 2065 Go Science8,4761
113parsnip 60 1163  8,4181
114Gumibear 60 2065  8,3861
115Mao Mao 60 287  8,3591
116jausmh 18 36 Marvin's bunch8,2981
117Anfinsen_slept_here 60 552 Go Science8,2771
118ZAxel91 60 2065  8,2731
119carsonfb 60 307  8,2431
120Superphosphate 60 2065 Gargleblasters8,2071
121pielie 60 2065  8,1841
122Jaco van&n... 60 2065  8,1041
123bcre8tvv 60 2065  8,0781
124cobaltteal 60 2065  8,0381
125joanieg 60 2065  7,9441

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# Comments

Offline
Joined: 10/02/2011
Let us mutate just a few

This puzzle is an example where letting us mutate just a few (like maybe 3) residues (of our choosing) might result in an even more stable fold. For example, residues 82-86 IRRRI - 2 oranges separated by 3 blues - make psipred think the final structure is a helix. They might make it fold as a helix too. But I'd be willing to bet it was designed as a sheet. Substituting an orange for the middle R would convince psipred that it was a sheet, and might make it actually fold into a sheet more reliably than the given sequence does.

You could give us the protein with a few mutations allowed as a separate puzzle, if you don't want to mess up the results of whatever experiment you are currently doing with us predicting foldit designs.

You could find any solutions that resemble the original design, run those mutated sequences through Rosetta, and compare the results using only backbone atoms to the original design, to see if you get better funnel-shaped graphs.

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