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1407: Medium Monomer Design Puzzle: Larger Core
Status: Closed
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Evolvers
1 | smilingone 94 2654 | Beta Folders | 10,495 | 100 | 2 | LociOiling 8 3 | Beta Folders | 10,494 | 97 | 3 | reefyrob 94 2654 | Beta Folders | 10,494 | 93 | 4 | matosfran 94 2654 | Beta Folders | 10,492 | 89 | 5 | Galaxie 5 9 | Anthropic Dreams | 10,480 | 85 | 6 | lamoille 94 2654 | Anthropic Dreams | 10,478 | 82 | 7 | retiredmichael 94 1653 | Beta Folders | 10,478 | 79 | 8 | phi16 13 17 | Anthropic Dreams | 10,410 | 75 | 9 | toshiue 14 253 | Go Science | 10,405 | 72 | 10 | Hollinas 68 1143 | Go Science | 10,390 | 69 | 11 | Bruno Kestemont 2 6 | Go Science | 10,386 | 66 | 12 | alwen 39 223 | Anthropic Dreams | 10,371 | 64 | 13 | alcor29 11 71 | Anthropic Dreams | 10,365 | 61 | 14 | andrewxc 94 2654 | Gargleblasters | 10,314 | 58 | 15 | Blipperman 29 44 | Gargleblasters | 10,312 | 56 | 16 | actiasluna 94 2654 | Gargleblasters | 10,289 | 53 | 17 | gitwut 94 2654 | Contenders | 10,218 | 51 | 18 | Bletchley Park 10 53 | Contenders | 10,214 | 49 | 19 | mimi 94 2654 | Contenders | 10,136 | 46 | 20 | georg137 42 116 | Contenders | 10,115 | 44 | 21 | Anfinsen_slept_here 43 50 | Go Science | 10,109 | 42 | 22 | jausmh 33 65 | Marvin's bunch | 10,033 | 40 | Need this puzzle? Log in to download.
Comments
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Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.
Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.
Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.
Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.
Residue Count: Penalizes extra residues inserted beyond the starting 75. Players may use up to 90 residues in total.
Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."