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1401: Small Monomer Design: Larger Core
Status: Closed
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Summary
| Name: |
1401: Small Monomer Design: Larger Core |
| Status: |
Closed |
| Created: |
07/07/2017 |
| Points: |
100 |
| Expired: |
07/14/2017 - 23:00 |
| Difficulty: |
Intermediate |
| Description: |
This puzzle challenges players to design a single-chain protein with 65-75 residues. The Core Existence filter has been escalated so that 35% of residues need to be buried in the protein core. The starting structure has 65 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions! |
| Categories: | Overall, Prediction |
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| Soloists | |
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| NinjaGreg 23 23 | 1712: Revisitin...xin | 11,734 | | Waya 6 8 | 1713: IL-7R Bin...d 5 | 11,591 | | silent gene 7 6 | 1714: Symmetric...ues | 22,982 | | silent gene 7 6 | 1715: IL-7R Bin...d 6 | 11,526 | | ComputerMage 76 618 | Beginner Puzzle...ign | 10,358 | | haiqu | Beginner Puzzle...yle | 8,223 | | Dj-P 76 281 | Beginner Puzzle...zle | 9,082 | | Dj-P 76 281 | Beginner Puzzle...nis | 9,958 | | Franco1947 76 1437 | Beginner Puzzle...ity | 15,963 | | Merf 76 54 | Beginner Puzzle...ign | 13,671 |
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| NinjaGreg 23 23 | 1712: Revisitin...xin | 11,734 | | Waya 6 8 | 1713: IL-7R Bin...d 5 | 11,591 | | silent gene 7 6 | 1714: Symmetric...ues | 22,982 | | silent gene 7 6 | 1715: IL-7R Bin...d 6 | 11,526 | | ComputerMage 76 618 | Beginner Puzzle...ign | 10,358 | | haiqu | Beginner Puzzle...yle | 8,223 | | Dj-P 76 281 | Beginner Puzzle...zle | 9,082 | | Dj-P 76 281 | Beginner Puzzle...nis | 9,958 | | Franco1947 76 1437 | Beginner Puzzle...ity | 15,963 | | Merf 76 54 | Beginner Puzzle...ign | 13,671 | |
| Go Science | 1712: Revisitin...xin | 11,734 | | Anthropic Dreams | 1713: IL-7R Bin...d 5 | 11,596 | | Go Science | 1714: Symmetric...ues | 22,982 | | Go Science | 1715: IL-7R Bin...d 6 | 11,526 | | Russian team | Beginner Puzzle...ign | 10,358 | | Go Science | Beginner Puzzle...yle | 6,713 | | Go Science | Beginner Puzzle...zle | 9,082 | | Go Science | Beginner Puzzle...nis | 9,958 | | Go Science | Beginner Puzzle...ity | 15,578 | | Go Science | Beginner Puzzle...ign | 13,109 | |
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Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.
Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.
Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.
Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.
Residue Count: Penalizes extra residues inserted beyond the starting 65. Players may use up to 75 residues in total.
Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."