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1366b: Electron Density Practice: Cell Surface Marker
Status: Closed


Name: 1366b: Electron Density Practice: Cell Surface Marker
Status: Closed
Created: 04/14/2017
Points: 100
Expired: 04/21/2017 - 23:00
Difficulty: Intermediate
Description: Note: This puzzle replaces Puzzle 1366, which was originally posted with an incorrect sequence.

This puzzle is meant for Foldit players to practice folding a protein with an electron density map. This electron density map was generated from x-ray diffraction at a resolution of 1.7 Å, and was published in March of 2017. The protein is only a portion of a much larger protein that is displayed on the surface of human dendritic cells, and plays an important role in the immune system. This protein includes two cysteines that oxidize to form one disulfide bond. Note that part of this protein is "disordered" in the original crystal structure; not all residues will fit into the density! Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

Categories: Electron Density, Overall, Prediction

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1Beta Folders14,003100
3Go Science13,96854
4Anthropic Dreams13,95238

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons