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1355: 100 Residue Monomer Design: Helix Restrictions
Status: Closed


Name: 1355: 100 Residue Monomer Design: Helix Restrictions
Status: Closed
Created: 03/18/2017
Points: 100
Expired: 03/26/2017 - 23:00
Difficulty: Intermediate
Description: This puzzle is similar to recent design puzzles except that we've restricted the use of SER and THR residues in α-helices. Foldit players have submitted some stellar-looking designs recently, but we are seeing quite a lot of SER and THR residues in designed helices. Recent experiments in our lab suggest that these residues are somewhat unfavorable in helices, so in this puzzle we've restricted the use of SER and THR in helical positions. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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