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1346: 80 Residue Monomer Design: Helix Restrictions
Status: Closed
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Evolvers
1 | Galaxie 1 2 | Anthropic Dreams | 10,567 | 100 | 2 | Bruno Kestemont 3 3 | Go Science | 10,555 | 98 | 3 | jermainiac 46 1390 | Anthropic Dreams | 10,551 | 95 | 4 | smilingone 46 1390 | Beta Folders | 10,545 | 92 | 5 | LociOiling 2 1 | Beta Folders | 10,545 | 89 | 6 | reefyrob 46 1390 | Beta Folders | 10,544 | 87 | 7 | jfryk 46 1390 | Anthropic Dreams | 10,539 | 84 | 8 | lamoille 46 1390 | Anthropic Dreams | 10,536 | 82 | 9 | phi16 9 30 | Anthropic Dreams | 10,534 | 79 | 10 | alwen 46 1390 | Anthropic Dreams | 10,520 | 77 | 11 | Hollinas 46 1390 | Go Science | 10,506 | 72 | 12 | JayD7217 46 1390 | Go Science | 10,498 | 70 | 13 | alcor29 5 9 | Anthropic Dreams | 10,490 | 68 | 14 | Anfinsen_slept_here 21 47 | Go Science | 10,411 | 66 | 15 | Bletchley Park 8 7 | Contenders | 10,411 | 64 | 16 | Blipperman 26 31 | Gargleblasters | 10,383 | 62 | 17 | smholst 46 1390 | Gargleblasters | 10,377 | 60 | 18 | ManVsYard 46 533 | Gargleblasters | 10,368 | 58 | 19 | gitwut 46 1390 | Contenders | 10,360 | 56 | 20 | georg137 18 33 | Contenders | 10,358 | 54 | 21 | spvincent 29 11 | Contenders | 10,263 | 52 | 22 | ViJay7019 46 1390 | Go Science | 10,244 | 51 | 23 | actiasluna 46 1390 | Gargleblasters | 9,879 | 49 | Need this puzzle? Log in to download.
Comments
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Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.
Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.
Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.
Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.
Residue Count: Penalizes extra residues inserted beyond the 80 residue limit. Players may insert up to 10 extra residues.
Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."