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spmm's picture
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Joined: 08/05/2010
Groups: Void Crushers

ScienceNow article: http://www.sciencemag.org/news/2017/01/hundreds-elusive-protein-structures-pinned-down-genome-data

http://science.sciencemag.org/content/355/6322/294 - Protein structure determination using metagenome sequence data Dr D Baker et al

Joined: 04/24/2014
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Thanks for this!

Thanks for this!

Susume's picture
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Joined: 10/02/2011
Very interesting

Very interesting; thanks for posting!

Joined: 09/24/2012
Groups: Go Science
Motivating !

"In rare cases, genetic mutations may alter both key amino acids at the same time, preserving their interaction so that the protein can continue to do its job. Evolution would favor such tandem mutations, which would cause the amino acid partners to coevolve."

"The trick to finding these coevolving pairs (...) was to look at the gene sequence of a protein from not just a single organism, but many".

And it worked !

"Baker’s group (...) was able to track enough coevolving amino acids to pin down the structures of 614 proteins, each one representing an entire family of proteins for which no structures exist".

Hopefully this kind of info would be build in our Foldit tools (Remix? Contact maps? I don't realize).

tokens's picture
User offline. Last seen 1 year 37 weeks ago. Offline
Joined: 11/28/2011
Contact maps

As far as I know, the contact maps in the recent contact map puzzles are generated from this coevolution data.


Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons