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1331: 75 Residue Monomer Design: Blueprint
Status: Closed

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RankGroupScorePoints
1Anthropic Dreams10,469100
2Beta Folders10,44373
3Contenders10,37552
4Gargleblasters10,36736
5Void Crushers10,32124
6Go Science10,28316
7L'Alliance Francophone10,20010
8Another Hour Another Point10,0756
9Italiani Al Lavoro9,4494
10Russian team9,2652
11Kotocycle8,6961
12uneRx7,3411
13xkcd7,3361
14DSN @ Home7,0461
15Natural Abilities4,9191
16SciOne201701
17test_group101


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bkoep's picture
User offline. Last seen 1 hour 26 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 75 residue limit. Players may insert up to 10 extra residues.

gitwut's picture
User offline. Last seen 3 years 20 weeks ago. Offline
Joined: 05/18/2012
Groups: Contenders
How are we supposed to know if a loop is ideal?

Without the ideal loop filter how are we supposed to know if a loop is ideal or not? Normally I'd use the "show" checkbox on the filter. Seems to me you should keep the filter without giving a penalty or bonus.

That or add something to remix that indicates whether or not the loop in question is ideal.

This is why remix is practically useless for non-design puzzles.

bkoep's picture
User offline. Last seen 1 hour 26 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Ideal loops not expected

We don't expect you to make Ideal Loops! We want to see what players can come up with if they are not restricted by the Ideal Loops Filter.

The Ideal Loop Filter has resulted in some very promising designs with much better backbones, but we don't know if it is necessary. It could be that Foldit players can find high-scoring, stable designs without it—especially now that Rebuild is disabled.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons