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1331: 75 Residue Monomer Design: Blueprint
Status: Closed

Summary

Name: 1331: 75 Residue Monomer Design: Blueprint
Status: Closed
Created: 01/19/2017
Points: 100
Expired: 01/26/2017 - 23:00
Difficulty: Intermediate
Description: This puzzle omits the Ideal Loop Filter; we're leaving it up to players to find their own high-scoring loops! The Blueprint panel is still available, which can be accessed from the Actions menu (or the Main menu in Selection Interface). Like other recent puzzles, the Rebuild action has been disabled here; in its place we encourage players to use Remix instead. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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Comments

bkoep's picture
User offline. Last seen 46 min 3 sec ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 75 residue limit. Players may insert up to 10 extra residues.

gitwut's picture
User offline. Last seen 37 weeks 2 days ago. Offline
Joined: 05/18/2012
Groups: Contenders
How are we supposed to know if a loop is ideal?

Without the ideal loop filter how are we supposed to know if a loop is ideal or not? Normally I'd use the "show" checkbox on the filter. Seems to me you should keep the filter without giving a penalty or bonus.

That or add something to remix that indicates whether or not the loop in question is ideal.

This is why remix is practically useless for non-design puzzles.

bkoep's picture
User offline. Last seen 46 min 3 sec ago. Offline
Joined: 11/15/2012
Groups: None
Ideal loops not expected

We don't expect you to make Ideal Loops! We want to see what players can come up with if they are not restricted by the Ideal Loops Filter.

The Ideal Loop Filter has resulted in some very promising designs with much better backbones, but we don't know if it is necessary. It could be that Foldit players can find high-scoring, stable designs without it—especially now that Rebuild is disabled.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons