bkoep's picture
User offline. Last seen 13 hours 13 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 75 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

Bautho's picture
User offline. Last seen 6 days 17 hours ago. Offline
Joined: 02/16/2012
Groups: Go Science
Wiggling destroys structure

I got a really strange thing.
After creating a nice fold with blueprint , wiggling and mutating residues I wiggled the whole structure in the very end, but instead of increasing the score it goes from 9822 points (including 810 bonus points) down into the 7000s and the beta-strands disassemble again.

I tried almost everything, but it always ends in this strange behavior. Also the Rama map looks perfect before wiggling...

Susume's picture
User offline. Last seen 10 hours 26 min ago. Offline
Joined: 10/02/2011
Remove blueprint constraints?

Before you wiggle that last time, try removing the constraints that are left behind by the blueprint tool. Open blueprint, and drag the rectangles off the sequence of letters. Then try the wiggle.

Bautho's picture
User offline. Last seen 6 days 17 hours ago. Offline
Joined: 02/16/2012
Groups: Go Science
Great, thanks!

You were right, there were still some squares left over the sequence.
Removing them helped a lot ;)
thanks

User login
Download links:
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.12 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media


Search
Only search fold.it
Other Games: Mozak
Recommend Foldit
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons