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1313: 85 Residue Monomer Design: Blueprint
Status: Closed

Summary

Name: 1313: 85 Residue Monomer Design: Blueprint
Status: Closed
Created: 12/03/2016
Points: 100
Expired: 12/10/2016 - 23:00
Difficulty: Intermediate
Description: Note: The starting structure has only 70 residues, but players are encouraged to add residues up to a total of 85! The disparity in residue number allows sharing of solutions from Puzzle 1302, which was posted with a faulty Residue Count filter and awarded no points. We apologize for any inconvenience!

This puzzle features the new Blueprint panel, which can be accessed from the Actions menu (or the Main menu in Selection Interface). See the blog for more information. Like other recent puzzles, the Rebuild action has been disabled here; in its place we encourage players to use Remix instead. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Anthropic Dreams10,692100
2Contenders10,69176
3Beta Folders10,67056
4Gargleblasters10,62141
5Go Science10,58229

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Comments

bkoep's picture
User offline. Last seen 2 days 13 hours ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 85 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

Joined: 09/24/2012
Groups: Go Science
95

I can go to 95 residues

Joined: 05/19/2009
Groups: Contenders
95 with a penalty of 10000

Bruno, yes you can but the penalty for adding residues over 85 should quickly deter you from doing so. I noticed a 10000 point penalty for 95 residues.

Joined: 09/24/2012
Groups: Go Science
yes

indeed, I didn't notice while I was in huge negative points

alwen's picture
User offline. Last seen 2 weeks 17 hours ago. Offline
Joined: 10/03/2011
This is the slowest puzzle

This is the slowest puzzle I've worked on recently. It takes my PC as long as 10 minutes to grind through 3 iterations of wiggle. The fact that I'm on the scoreboard at all is only due to my stubbornness.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons