puzzle picture
1269: 90 Residue Monomer Design: More Sheets!
Status: Closed

Summary

Name: 1269: 90 Residue Monomer Design: More Sheets!
Status: Closed
Created: 08/06/2016
Points: 100
Expired: 08/15/2016 - 23:00
Difficulty: Intermediate
Description: This puzzle challenges players to design proteins with more sheets! Designs should include at least 50% residues in sheet conformation. The Ideal Loops Filter is meant to encourage the use of the Ideal Loops that are displayed in the Rama Map. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Contenders10,603100
2Anthropic Dreams10,57565
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4L'Alliance Francophone10,48424
5Void Crushers10,40014

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RankPlayerGroupScorePoints
1dcrwheeler 81 11  10,578100
2tokens 81 1328 Anthropic Dreams10,57397
3Mark- 81 1328 Contenders10,55094
4Scopper 81 1328 Go Science10,52291
5fiendish_ghoul 81 7  10,51588


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Comments

bkoep's picture
User offline. Last seen 2 hours 19 min ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that at least 50% of residues are in sheets; penalties are incurred if fewer than 50% of residues form sheets.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 90 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons