1266: Disordered Electron Density: Crystal Symmetry
|Name:||1266: Disordered Electron Density: Crystal Symmetry|
|Expired:||08/08/2016 - 23:00|
|Description:||Note: This puzzle is worth zero points, and will not affect player rankings. Solutions from Puzzle 1230 or Puzzle 1221 cannot be loaded correctly into this puzzle; players should avoid loading previous solutions into this puzzle.
This is a followup to Puzzle 1230, now with crystal symmetry! Many of the solutions from Puzzle 1230 had severe clashes when modeled in the crystal lattice; this puzzle includes nearby symmetric copies in the crystal lattice. Because it is slow to display all symmetric proteins, we recommend that players hide the symmetric copies during most of their folding. You can hide symmetric copies in the View menu by unchecking the box "Show Symmetric Chains" (make sure you've already checked Menu->General Options->Show advanced GUI).
This electron density puzzle features two proteins: the first is a large well-ordered helical protein that is mostly frozen in place. This binder protein has two flexible loops that bind a second, mostly disordered, substrate protein. The substrate protein is provided here as an extended chain, and is completely flexible. We know that the substrate protein is bound to the binder protein somewhere in this crystal structure. But it seems that the substrate is able to adopt several different shapes, making the electron density very difficult to interpret. We’re asking Foldit players to help us find the ways that the substrate protein can bind to the binder protein! Fold up the extended chain and dock it next to the flexible loops of the binder to improve your score!
|Categories:||Electron Density, Overall, Prediction|
Need this puzzle? Log in to download.