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Joined: 05/26/2008
Groups: Hold My Beer

Just an idea here, but it sounded good in my head ;)

How about design puzzles where you start with a small known protein that is useful or interesting.

Once it is loaded allow design as normal, however:

Limit swapping amino acids to changes from the same group and grant a small bonus for deviation from the original sequence.

Joined: 03/30/2013
Groups: Go Science
Yes. I like the idea. We

Yes. I like the idea. We could design mini-antibodies to new ligands/antigens. We could re-design known clefts to bind transition-state analogs in hopes of getting new enzymes (I hope that idea isn't too 1980's- 19990's). We could work on stuff that binds to environmental toxins for bio-remediation. Lot of potential I think.

Joined: 10/23/2014
Groups: Contenders
Somewhat similar to 1059

This reminds me somewhat of puzzle 1059.

You are given a set design and asked to improve it. You can change the shape of the design up to a set limit but over that limit you are penalized. You can change amino acids but I would think you are somewhat limited by the shape of the design.


Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons