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Here is a recent paper from the Baker Lab in which they inserted one small designed protein into another, thus creating a larger designed protein. This demonstrates a new method for creating larger designed proteins, and it may be a pathway by which some natural proteins evolved from smaller building blocks.

Precise assembly of complex beta sheet topologies from de novo designed building blocks
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737653/

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons