puzzle picture
1221: Disordered Electron Density: Round 1
Status: Closed

Summary

Name: 1221: Disordered Electron Density: Round 1
Status: Closed
Created: 04/17/2016
Points: 0
Expired: 04/24/2016 - 23:00
Difficulty: Advanced
Description: NOTE: Because many players have had trouble playing this puzzle, the puzzle has been made worth zero points, and it will not contribute to player rankings. However, this puzzle is still of unique scientific interest, and we encourage players to work on it if they are able!

This is a big one! This electron density puzzle features two proteins: the first is a large well-ordered helical protein that is mostly frozen in place. This binder protein has two flexible loops that bind a second, mostly disordered, substrate protein. The substrate protein is provided here as an extended chain, and is completely flexible. We know that the substrate protein is bound to the binder protein somewhere in this crystal structure. But it seems that the substrate is able to adopt several different shapes, making the electron density very difficult to interpret. We’re asking Foldit players to help us find the ways that the substrate protein can bind to the binder protein! Fold up the extended chain and dock it next to the flexible loops of the binder to improve your score!
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bertro's picture
User offline. Last seen 1 week 5 days ago. Offline
Joined: 05/02/2011
Groups: Beta Folders
and this is Crash info on re-starting client:

===>>> Log.txt

args passed:
'F:\FolditNEW\Main A\Foldit\Foldit.exe'
starting the init thread!..
boinc base url: https://fold.it
checking updates...
binary
local: 'c2642c6c2819dc6eb1eccc7dfce6539b'
remote: 'c2642c6c2819dc6eb1eccc7dfce6539b'
database
local: '45bbcddcbd4174e67b82569775fde821'
remote: '45bbcddcbd4174e67b82569775fde821'
resources
local: 'f3f5689675a05a73fb3d5d1f6e8950e6'
remote: 'f3f5689675a05a73fb3d5d1f6e8950e6'
cleaning up old components:
binary 00000000000000000000000000000000
binary c2642c6c2819dc6eb1eccc7dfce6539b
database 45bbcddcbd4174e67b82569775fde821
resources 00000000000000000000000000000000
resources f3f5689675a05a73fb3d5d1f6e8950e6
SoundTheme::load: cmp-resources-f3f5689675a05a73fb3d5d1f6e8950e6\resources\sounds/organic_01
loading: cmp-resources-f3f5689675a05a73fb3d5d1f6e8950e6\resources\sounds/organic_01/rotamer_land_00.ogg
loading: cmp-resources-f3f5689675a05a73fb3d5d1f6e8950e6\resources\sounds/organic_01/rotamer_land_01.ogg
loading: cmp-resources-f3f5689675a05a73fb3d5d1f6e8950e6\resources\sounds/organic_01/rotamer_land_02.ogg
loading: cmp-resources-f3f5689675a05a73fb3d5d1f6e8950e6\resources\sounds/organic_01/rotamer_land_03.ogg
loading: cmp-resources-f3f5689675a05a73fb3d5d1f6e8950e6\resources\sounds/organic_01/rotamer_land_04.ogg
loading: cmp-resources-f3f5689675a05a73fb3d5d1f6e8950e6\resources\sounds/organic_01/rotamer_land_05.ogg
SVM classifier successfully loaded
Feature list successfully loaded
Valid classifier feature list
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue LEU:CtermProteinFull 21
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue GLU:CtermProteinFull 21
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue LYS:CtermProteinFull 21
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue ARG:CtermProteinFull 21
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue ASP:CtermProteinFull 21
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue LEU:CtermProteinFull 17
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue THR:CtermProteinFull 16
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue VAL:CtermProteinFull 17
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue ARG:CtermProteinFull 17
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue LYS:CtermProteinFull 16
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue ASN:CtermProteinFull 16
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue GLU:CtermProteinFull 16
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue ASP:CtermProteinFull 13
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue ARG:CtermProteinFull 12
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue GLU:CtermProteinFull 12
[0mcore.conformation.Conformation: [0m[ WARNING ] missing heavyatom: OXT on residue ASN:CtermProteinFull 12
buildid: 20160331-69bf47620a-win_x86-devprev
about to create view_options_button_
Duplicate hotkey Shift+L (Show outlines, )
setting side chain mode to: 0 Don't Show (Fast)
Playing: sounds/organic_01/splashscreen.ogg
Converting any old-style quicksaves and autosaves...
Deleting any old temporary autosaves and quicksaves...
Reading in vall_torsions file: cmp-database-45bbcddcbd4174e67b82569775fde821\database\sampling/rna/1jj2.torsions
Lines read from vall_torsions file: 2754
Sending SOPs:

Sending SOPs:

About to show the puzzle screen...
Trying to get the puzzle list...
Loading cache...
Parsing puzzle URL...
Parsing contests...
Parsing macros...
Saving the cache...
Parsing level completion...
Sending SOPs:

Initting the list...
Got the puzzles...
Sending SOPs:

Finished show_puzzle_screen...
has key .odensity
has key .owts
has key .params
has key .2.params
has key .opdb
has key .opuzzle_setup
has key .ocnstr
starting score : 7164.54
puzzle loaded
[0mWarning: [0mUnable to locate database file chemical/gasteiger/default/atom_type_data.txt
[0m[1m[31m
ERROR: Unable to open gasteiger atom type file: cmp-database-45bbcddcbd4174e67b82569775fde821\database\chemical/gasteiger/default/atom_type_data.txt
ERROR:: Exit from: ..\..\..\source\src\core\chemical\gasteiger\GasteigerAtomTypeSet.cc line: 58
[0m
UNHANDLED EXCEPTION
1: RaiseException +72 bytes (no line)
2: library_main +46809519 bytes (no line)
3: library_main +44830496 bytes (no line)
4: library_main +44218969 bytes (no line)
5: library_main +42812450 bytes (no line)
6: library_main +4279842 bytes (no line)
7: library_main +4138407 bytes (no line)
8: library_main +3254560 bytes (no line)
9: library_main +3251722 bytes (no line)
10: library_main +407818 bytes (no line)
11: library_main +663143 bytes (no line)
12: library_main +3310807 bytes (no line)
13: library_main +3386333 bytes (no line)
14: library_main +678689 bytes (no line)
15: library_main +675098 bytes (no line)
16: library_main +841039 bytes (no line)
17: library_main +480242 bytes (no line)
18: library_main +861729 bytes (no line)
19: library_main +549791 bytes (no line)
20: library_main +404801 bytes (no line)
21: library_main +4356837 bytes (no line)
22: library_main +4357291 bytes (no line)
23: BaseThreadInitThunk +36 bytes (no line)
24: RtlUnicodeStringToInteger +595 bytes (no line)
25: RtlUnicodeStringToInteger +542 bytes (no line)

===>>> Debug.txt

version: 1
{
"build_id" : "20160331-69bf47620a-win_x86-devprev"
"crash_id" : "cd7681d6-1aa9-4671-b5a1-aefb58761187"
"current_actions" : ""
"current_tool" : ""
"file" : "core/chemical/gasteiger/GasteigerAtomTypeSet.cc:58"
"machine_id" : "09edfe6b-95dc-4576-888d-aeeae5d74622"
"macro_id" : "-1"
"message" : "Unable to open gasteiger atom type file: cmp-database-45bbcddcbd4174e67b82569775fde821\\database\\chemical/gasteiger/default/atom_type_data.txt"
"player_id" : "253386"
"puzzle_id" : "2002315"
"puzzle_running_time" : "0"
"running_time" : "2.5774e+006"
"timestamp" : "1461162818"
}
verify: bed796190956960a92ef109636f44c5a

Joined: 08/19/2014
Groups: Gargleblasters
Will puzzle still affect

Will puzzle still affect achievements like moves and top 10, 20, 30? If not I may just save and wait on it.

Joined: 09/24/2012
Groups: Go Science
as I understood from the News:

1) Zero points means that it will not change anything in our overall ranking (=> indeed you may save and wait)

2) If they technically succeed "allowing players to load solutions from this puzzle", then the ones with a high solution for this puzzle would have an advantage on the others for second round.

From an overall ranking point of view, playing this puzzle is thus a "small positive sum game". :D

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons