puzzle picture
1208: 75 Residue Monomer Design: Rama Map
Status: Closed

Summary

Name: 1208: 75 Residue Monomer Design: Rama Map
Status: Closed
Created: 03/16/2016
Points: 100
Expired: 03/24/2016 - 23:00
Difficulty: Intermediate
Description: This puzzle premieres a new tool, the Rama Map, which is meant to give players more control of the protein backbone. The Rama map can be accessed from the Actions tab (Original Interface) or the Main menu (Selection Interface). See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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RankGroupScorePoints
1Contenders10,416100
2Beta Folders10,41382
3Go Science10,39866
4Anthropic Dreams10,38953
5Gargleblasters10,37142

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Comments

bkoep's picture
User offline. Last seen 2 days 3 hours ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons