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1205: 75 Residue Monomer Design: Helical Bundles
Status: Closed

Summary

Name: 1205: 75 Residue Monomer Design: Helical Bundles
Status: Closed
Created: 03/10/2016
Points: 100
Expired: 03/17/2016 - 23:00
Difficulty: Intermediate
Description: This is a basic 75 residue design puzzle with no secondary structure filter—helical bundles welcome! Ideality scoring is also up-weighted, so players should take care that all cutpoints are closed with good geometry! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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RankGroupScorePoints
1Contenders10,091100
2Beta Folders10,07780
3Anthropic Dreams10,06363
4Go Science10,06249
5Void Crushers9,96537

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Comments

bkoep's picture
User offline. Last seen 18 min 13 sec ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons