puzzle picture
1202: 75 Residue Monomer Design
Status: Closed

Summary

Name: 1202: 75 Residue Monomer Design
Status: Closed
Created: 03/04/2016
Points: 100
Expired: 03/10/2016 - 23:00
Difficulty: Intermediate
Description: This is a basic 75 residue design puzzle with slightly up-weighted ideality scoring. Players should take care that all cutpoints are closed with good geometry! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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Comments

bkoep's picture
User offline. Last seen 1 day 21 hours ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Joined: 06/06/2013
Groups: Gargleblasters
can we list total points for filters please

Often during set up I may ignore some filters. It would be handy to post total filter points once I am ready to move from hand folding to recipes, as many ask for total filter score. I have been guessing...
Thanks

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons