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1202: 75 Residue Monomer Design
Status: Closed
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Summary
| Name: |
1202: 75 Residue Monomer Design |
| Status: |
Closed |
| Created: |
03/03/2016 |
| Points: |
100 |
| Expired: |
03/10/2016 - 23:00 |
| Difficulty: |
Intermediate |
| Description: |
This is a basic 75 residue design puzzle with slightly up-weighted ideality scoring. Players should take care that all cutpoints are closed with good geometry! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions! |
| Categories: | Design, Overall |
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Comments
Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.
Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.
Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.
Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.