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1199: 70 Residue Monomer Design
Status: Closed

Summary

Name: 1199: 70 Residue Monomer Design
Status: Closed
Created: 02/25/2016
Points: 100
Expired: 03/03/2016 - 23:00
Difficulty: Intermediate
Description: This is a basic 70 residue design puzzle with slightly up-weighted backbone scoring. Players should take care that all residues have a good backbone score! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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Comments

bkoep's picture
User offline. Last seen 2 hours 5 min ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Joined: 09/24/2012
Groups: Go Science
Ligand

Is it normal that seg 70 is recognized as ligand?

Joined: 10/30/2012
Groups: Beta Folders
you probably used auto

you probably used auto structures, when you do it will turn segment70 into a ligand. been a long time issue with auto structure. Loci has been looking at it for months and has even modified a few recipes to deal with it.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons