puzzle picture
Beginner Puzzle (<150): Docking Design
Status: Closed

Summary

Name: Beginner Puzzle (<150): Docking Design
Status: Closed
Created: 01/27/2014
Points: 100
Expired: 02/11/2016 - 23:00
Difficulty: Beginner
Description: We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.

START HERE:

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864
_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :
- try all puzzles not only "Beginners" ones,
- fold first the ones you like the most,
- try it by yourself to understand what works and what doesn't,
- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:
- Lonely Sheets,
- Lock and Lower,
- Rebuild,
- Structure and Rebuild,
- Movin' Along,
- Control over Clashing,
- Intro to Design,
- Swappin' Sidechains,
- Mass Mutate,
- Insertion and Deletion

before starting this puzzle.

Categories: Beginner

Top Groups

RankGroupScorePoints
1xkcd8,866100
2TS Biology 8,85783
3CSE1628,83069
4Go Science8,82956
5EVHS AP Biology8,80345

Top Soloists

RankPlayerGroupScorePoints
118539904_Makhubo 81 1314  9,078100
2dahast.de 81 537  9,018100
3thatswave 81 1314  8,98999
4chaperone87 81 1314  8,93498
5diamonddays 81 64  8,93498


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Comments

kesch16's picture
User offline. Last seen 3 years 22 weeks ago. Offline
Joined: 02/14/2016
Groups: NFS 3083 2016
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Status: Closed
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons