puzzle picture
1171: 60 Residue Symmetric Dimer Design: H-Bond Networks
Status: Closed

Summary

Name: 1171: 60 Residue Symmetric Dimer Design: H-Bond Networks
Status: Closed
Created: 12/17/2015
Points: 100
Expired: 12/24/2015 - 23:00
Difficulty: Intermediate
Description: In this puzzle, the bonus for Hbond networks has been increased, but only Hbond networks that are at least 75% satisfied will be rewarded. Furthermore, no more than three inter-molecular Hbonds may contribute to the filter! There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

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Comments

bkoep's picture
User offline. Last seen 18 hours 5 min ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with 1-4 hydrogen bonds spanning the dimer interface. In addition, at least 75% of all polar atoms in the network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 18 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 48 residues are buried in the core of the entire complex (including the interface between monomer units).

Joined: 09/19/2011
Groups: Beta Folders
bkoep... it seems that most

bkoep... it seems that most can't access this puzzle in client. Does it require an old client to play it?

alwen's picture
User offline. Last seen 1 day 16 hours ago. Offline
Joined: 10/03/2011
Not only does this puzzle not

Not only does this puzzle not show in my Puzzle Menu, it also does not show up in the "Social" tab.

Usually, in the Social tab, all puzzles show up, even before they are released, but 1171 doesn't.

bertro's picture
User offline. Last seen 21 hours 41 min ago. Offline
Joined: 05/02/2011
Groups: Beta Folders
I do not see this puzzle even with latest update

I do not see this puzzle even with latest update

Joined: 11/18/2012
Groups: None
Puzzle not in puzzle menu

I do not see this puzzle in my puzzle menu either. I also have the latest update.

gmn's picture
User offline. Last seen 3 weeks 4 days ago. Offline
Joined: 08/20/2010
not in main or devprev

I cannot see puzzle with recent updates for either main or devprev.

Joined: 04/11/2013
Nope

Don't see it. Even typing the puzzle number in the box.

Joined: 09/24/2012
Groups: Go Science
I can see it on a Mac, updated client

not on windows, neither devprev neither main neither old client neither new one

Joined: 07/21/2013
Groups: Beta Folders
I can not see puzzle 1171

I am running Windows 10. I am using devprev (see below)
C:\FolditLogs>ver

Microsoft Windows [Version 10.0.10240]

buildid: 20151215-9e58b22c38-win_x86-devprev

I see no option to download my error file as in the feedback
section.

Here is a segment of my error file when I attempted to download
puzzle 1171.

Notice : This nickname is registered and protected. If it is your
Notice : nick, type /msg NickServ IDENTIFY password. Otherwise,
Notice : please choose a different nick.
Notice : Password accepted - you are now recognized.
IDENTIFIED
Private message : message t1450429795.7658 b48b737ceaeb0d71ccb3d4634478f59e puzzle 2001672
download puzzle: 2001672
exiting...
Option file found. Sending...
closing boinc...
Sending SOPs:

done.
IRC::run error, code = 5, desc = Remote connection closed
Exiting IRC::run

frood66's picture
User offline. Last seen 6 hours 5 min ago. Offline
Joined: 09/20/2011
Groups: Marvin's bunch
setting focal point

'shift q' inoperative. Mac.

Joined: 04/24/2014
Groups: None
Investigating

Thanks for the heads up!

gloverd's picture
User offline. Last seen 44 weeks 1 day ago. Offline
Joined: 11/19/2012
Groups: Go Science
I have a mac and can work on

I have a mac and can work on 1171 no problem.

bkoep's picture
User offline. Last seen 18 hours 5 min ago. Offline
Joined: 11/15/2012
Groups: None
Thank you all for your timely feedback!

We appreciate your promptness, and apologize for the delayed response. We had hoped to identify a quick fix, but it seems that will not happen. This puzzle has been closed early.

Your comments are especially helpful to us in tracking down the problem. Thank you for your patience!

jflat06's picture
User offline. Last seen 1 week 1 day ago. Offline
Joined: 09/29/2010
Groups: Window Group
.

This puzzle has be re-opened now that we've discovered and fixed an issue with the Windows client that was preventing it from being seen and opened.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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