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1147b: 75 Residue Symmetric Dimer Design: Satisfied H-Bonds
Status: Closed


Name: 1147b: 75 Residue Symmetric Dimer Design: Satisfied H-Bonds
Status: Closed
Created: 10/11/2015
Points: 100
Expired: 10/18/2015 - 23:00
Difficulty: Intermediate
Description: Note: This puzzle replaces Puzzle 1147 which was closed early due to a bug in the HBNet filter. Players will be able to load in solutions from Puzzle 1147.

In this puzzle, the bonus for Hbond networks has been increased, but only Hbond networks that are at least 75% satisfied will be rewarded. Furthermore, no more than three inter-molecular Hbonds may contribute to each network! There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

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1Anthropic Dreams13,872100
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bkoep's picture
User offline. Last seen 10 hours 35 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Residue IE Score: Monitors

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with at least one hydrogen bond spanning the dimer interface. In addition, at least 75% of all polar atoms in the network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 24 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 62 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Joined: 09/24/2012
Groups: Go Science
cannot load 1147 solutions

Cannot load former Devprev solution from Main (on Windows). It works from devprev and I can share but unable to share with main.
"Error ... bad pose version"

Joined: 09/24/2012
Groups: Go Science
I shared it to scientist

as B1 devprev

Joined: 05/19/2009
Groups: Contenders
Scores affected by a scoring bug.

This scoring bug affects the scores of this puzzle.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons