1144: How low can you go? 10-residue Marburg binder design
|Name:||1144: How low can you go? 10-residue Marburg binder design|
|Expired:||10/10/2015 - 23:00|
|Description:||This is the next in our series of Ebola/Marburg puzzles. We want you to design an ultra-small cyclic peptide to bind to and neutralize the Marburg virus glycoprotein. The glycoprotein is involved in viral entry into cells, and binding to a particular spot in the "head" region of this protein inhibits its interaction with human cells and abolishes its activity, neutralizing the virus.
We're giving you a ten-residue peptide with a disulfide bond linking the ends of the peptide. Two residues in the middle are taken from a loop of an antibody that binds to this head region. We want you to design the rest of the peptide to maximize favourable interactions, both within the peptide and with the Marburg glycoprotein. Pay particular attention to backbone hydrogen bonding -- the backbone hydrogen bond score has been upweighted for this puzzle.
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