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Joined: 11/15/2012
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Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with at least one hydrogen bond spanning the dimer interface. In addition, at least 75% of all polar atoms in the network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 18 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 66 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Joined: 04/10/2015
Groups: Beta Folders
Go for more HBN

Is it possible to get for a next Hbond Puzzle instead of a dimer or a trimer a fourmer (is it right in English?) ?

With lower Monomer requirement (20% instead of 30%) and more interfase requirement (30% instead of 20%).

Joined: 04/20/2012
Groups: Go Science
4-mer = tetramer

1-mer = monomer
2-mer = dimer
3-mer = trimer
4-mer = tetramer
5-mer = pentamer
6-mer = hexamer

Joined: 04/10/2015
Groups: Beta Folders
thanks for the language

thanks for the language clarification...

bkoep's picture
User offline. Last seen 28 min 53 sec ago. Offline
Joined: 11/15/2012
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Literature on satisfying hydrogen bonds

For those interested in why hydrogen bond networks need to be satisfied, see this paper by Fleming and Rose:
http://onlinelibrary.wiley.com/doi/10.1110/ps.051454805/full

For easier reference, I've also posted in a comment on the HBNet Filter blog entry:
http://fold.it/portal/node/2000666#comment-31017

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