3 replies [Last post]
Joined: 08/05/2015
Groups: None

In the Wikipedia article on protein folding, I read:

The process of folding often begins co-translationally, so that the N-terminus of the protein begins to fold while the C-terminal portion of the protein is still being synthesized by the ribosome.

I understand that this means that a protein will start curling up from one end, like a retractable tape measure, starting at one end. I imagine that one strategy for playing foldit would be to start at the N-terminus of the protein, find which parts of the developing protein are attracted to each other, and create a first-pass shape for the new chain. A second pass could then be used to compact the first-pass shape into a glob, and then the Wiggle tools could be used to find the lowest energy position associated with the compacted shape.

Is this a technique that successful folders are using?

Is there a place where the highest-scoring hand-folders share their techniques?

spvincent's picture
User offline. Last seen 3 hours 55 min ago. Offline
Joined: 12/07/2007
Groups: Contenders
See this thread in the

See this thread in the Rosetta forums


Short answer: unfortunately that technique is unlikely to be useful.

jeff101's picture
User offline. Last seen 1 day 18 hours ago. Offline
Joined: 04/20/2012
Groups: Go Science
I think proteins can refold themselves:

I think people have done experiments where they change the solvent/temperature to make a protein unfold and then change the solvent/temperature again to make the protein refold into its desired conformation. If anyone knows a good reference about this, please post it here. Thanks!

jeff101's picture
User offline. Last seen 1 day 18 hours ago. Offline
Joined: 04/20/2012
Groups: Go Science
Black Belt Folding videos:

http://fold.it/portal/node/1998737 and http://foldit.wikia.com/wiki/BBF
have links to a series of Black Belt Folding videos.

The Foldit wiki has some pages about folding strategies.
See http://foldit.wikia.com/wiki/Strategy for example.


Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons