puzzle picture
1109: 80 Residue Symmetric Dimer Design: HBNet
Status: Closed

Soloists

RankPlayerGroupScorePoints
126momadoc 79 410  6,4163
127martinf 79 468  6,3662
128joaniegirl 79 445  6,2822
129lacie 79 1590  6,2622
130sharondipity 79 778  6,0822
131dahast.de 79 129  5,8772
132abiogenesis 79 126  5,8172
133tscherulli 79 1590  5,5112
134agnairt 79 1590  5,4502
135dettingen 63 778  5,4132
136dinoboy11 79 1590  5,3822
137johngran 79 163  4,9522
138rinze 79 78  4,7272
139wilding2004 79 1590 CureCoin4,4732
140lange 79 1590  4,4352
141cnhrcolemam 79 822  4,3441
142Punktchen 79 1590  4,2351
143Aldrovanda 79 1590  4,1031
144pandabearsecond 79 1590 Go Science3,9331
145Philippe_C 79 410  3,7971
146cor2020 79 1590  3,4211
147XyberX 79 1590  3,3881
148Ronndog 79 1590  3,3511
149emdee314 79 1590  3,2251
150Ciccillo 79 898 Italiani Al Lavoro3,2081


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Comments

bkoep's picture
User offline. Last seen 10 hours 45 min ago. Offline
Joined: 11/15/2012
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Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with at least one hydrogen bond spanning the dimer interface.

Core Existence: Monomer: Ensures that at least 24 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 54 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

bkoep's picture
User offline. Last seen 10 hours 45 min ago. Offline
Joined: 11/15/2012
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Inconsistent scoring

Some players have reported a scoring anomaly in similar puzzles; we think this problem will be less pronounced here, but please share with us if you encounter scoring problems when loading a solution!

Joined: 06/24/2008
Groups: Void Crushers
Helices or Not??

Question about 1109. All out H-Bond puzzles have been helices should this be all helices?

bkoep's picture
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Joined: 11/15/2012
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Anything and everything!

All-helical designs are just fine in this puzzle.

Yet, as always, we encourage players to experiment and try new things! We always take a close look at designs that players Share with Scientists, and here we are especially excited to see what players can do with hydrogen bond networks!

Joined: 07/05/2015
Groups: None
Need help

I can't find out how to play the fold it game.

Susume's picture
User offline. Last seen 1 week 6 days ago. Offline
Joined: 10/02/2011
HB nets vs. complex core filter

Some on my team are finding that HB nets in the interface push the monomers apart a little (compared with all hydrophobes in the interface) and this causes the loss of the complex core filter points. Because the complex core filter is so discontinuous (huge gain or loss of points all at once) and the HB net points are gained or lost a few at a time, it is hard or impossible to trade out just a few hydrophobes for polars and keep one's score up.

Do natural dimers have a mix of hydrophobes and polars in the interface? If so, maybe an adjustment to the complex core filter is needed. If not, such a mix may not be feasible.

bkoep's picture
User offline. Last seen 10 hours 45 min ago. Offline
Joined: 11/15/2012
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Thanks for the feedback!

Yes, natural interfaces tend to have a mixture of hydrophobic and polar interactions.

To be clear, polar residues do contribute to the Core Existence filter. Though, I can see how H-bonding polar residues might have a tendency to push subunits apart from one another to open up the interface—especially if you're simply trying to modify a pre-formed, all-hydrophobic interface. We will consider adjusting the Complex Core Existence filter for future puzzles, thanks for the feedback!

Susume's picture
User offline. Last seen 1 week 6 days ago. Offline
Joined: 10/02/2011
Voids

If you keep hydrophobes in the middle of the interface and make HB nets around the edges, the nets still force the monomers apart a bit, causing voids to form in the interface.

AryehK's picture
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Joined: 12/11/2014
Groups: Go Science
Re: need help

I reccomend Foldit Wiki for foldit advice
foldit.wikia.com/wiki/Foldit_Wiki

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