puzzle picture
1109: 80 Residue Symmetric Dimer Design: HBNet
Status: Closed

Soloists

RankPlayerGroupScorePoints
126momadoc 78 367  6,4163
127martinf 78 737  6,3662
128joaniegirl 78 491  6,2822
129lacie 78 1437  6,2622
130sharondipity 78 1437  6,0822
131dahast.de 78 543  5,8772
132abiogenesis 78 86  5,8172
133tscherulli 78 1437  5,5112
134agnairt 78 1437  5,4502
135dettingen 78 707  5,4132
136dinoboy11 78 1437  5,3822
137johngran 78 123  4,9522
138rinze 78 179  4,7272
139wilding2004 78 1437 CureCoin4,4732
140lange 78 190  4,4352
141cnhrcolemam 78 1437  4,3441
142Punktchen 78 1437  4,2351
143Aldrovanda 78 1437  4,1031
144pandabearsecond 78 1437 Go Science3,9331
145Philippe_C 78 491  3,7971
146cor2020 78 1437  3,4211
147XyberX 78 1437  3,3881
148Ronndog 78 1437  3,3511
149emdee314 78 1437  3,2251
150Ciccillo 78 737 Italiani Al Lavoro3,2081


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Comments

bkoep's picture
User offline. Last seen 4 hours 11 min ago. Offline
Joined: 11/15/2012
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Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with at least one hydrogen bond spanning the dimer interface.

Core Existence: Monomer: Ensures that at least 24 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 54 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

bkoep's picture
User offline. Last seen 4 hours 11 min ago. Offline
Joined: 11/15/2012
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Inconsistent scoring

Some players have reported a scoring anomaly in similar puzzles; we think this problem will be less pronounced here, but please share with us if you encounter scoring problems when loading a solution!

Joined: 06/24/2008
Groups: Void Crushers
Helices or Not??

Question about 1109. All out H-Bond puzzles have been helices should this be all helices?

bkoep's picture
User offline. Last seen 4 hours 11 min ago. Offline
Joined: 11/15/2012
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Anything and everything!

All-helical designs are just fine in this puzzle.

Yet, as always, we encourage players to experiment and try new things! We always take a close look at designs that players Share with Scientists, and here we are especially excited to see what players can do with hydrogen bond networks!

Joined: 07/05/2015
Groups: None
Need help

I can't find out how to play the fold it game.

Susume's picture
User offline. Last seen 1 hour 43 min ago. Offline
Joined: 10/02/2011
HB nets vs. complex core filter

Some on my team are finding that HB nets in the interface push the monomers apart a little (compared with all hydrophobes in the interface) and this causes the loss of the complex core filter points. Because the complex core filter is so discontinuous (huge gain or loss of points all at once) and the HB net points are gained or lost a few at a time, it is hard or impossible to trade out just a few hydrophobes for polars and keep one's score up.

Do natural dimers have a mix of hydrophobes and polars in the interface? If so, maybe an adjustment to the complex core filter is needed. If not, such a mix may not be feasible.

bkoep's picture
User offline. Last seen 4 hours 11 min ago. Offline
Joined: 11/15/2012
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Thanks for the feedback!

Yes, natural interfaces tend to have a mixture of hydrophobic and polar interactions.

To be clear, polar residues do contribute to the Core Existence filter. Though, I can see how H-bonding polar residues might have a tendency to push subunits apart from one another to open up the interface—especially if you're simply trying to modify a pre-formed, all-hydrophobic interface. We will consider adjusting the Complex Core Existence filter for future puzzles, thanks for the feedback!

Susume's picture
User offline. Last seen 1 hour 43 min ago. Offline
Joined: 10/02/2011
Voids

If you keep hydrophobes in the middle of the interface and make HB nets around the edges, the nets still force the monomers apart a bit, causing voids to form in the interface.

AryehK's picture
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Joined: 12/11/2014
Groups: Go Science
Re: need help

I reccomend Foldit Wiki for foldit advice
foldit.wikia.com/wiki/Foldit_Wiki

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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