puzzle picture
1102: Integrated Abeta Design
Status: Closed

Summary

Name: 1102: Integrated Abeta Design
Status: Closed
Created: 06/17/2015
Points: 100
Expired: 06/24/2015 - 23:00
Difficulty: Intermediate
Description: This large protein (291 residues!) is based on a prenyltransferase protein from Streptomyces; however, we've inserted the sequence of Aβ into residues 267-291. We're asking Foldit players to redesign this protein so that it folds up normally with the integrated Aβ! Such a protein could serve as a starting point for the design of an Aβ binder.

Because this protein is so large, the backbone has been frozen; players may design all residues except 267-291 (Aβ sequence). Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Hun-Magyar Csapat12,557100
2Go Science12,55781
3Russian team12,49964
4Beta Folders12,49050
5L'Alliance Francophone12,48039

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Comments

Joined: 09/24/2012
Groups: Go Science
coloring Aß

It would be nice if the non-mutable segments 267-291 would be in another colour.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons