bkoep's picture
User offline. Last seen 14 hours 32 min ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 22 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 50 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Joined: 09/24/2012
Groups: Go Science
strange

I've a solution with all bonus ok including core existence complex BUT my 2 monomers are still far away from each other ...

Joined: 10/30/2012
Groups: Beta Folders
me too

me too

bkoep's picture
User offline. Last seen 14 hours 32 min ago. Offline
Joined: 11/15/2012
Groups: None
Thanks for the feedback!

This came up in Puzzle 1068, as well:
http://fold.it/portal/node/2000548#comment-30118

If your monomer units are especially well-packed, it is possible to pass the "Core Existence: Complex" filter without designing an interface. We've intentionally set a low threshold here to allow more diversity in designs.

At some point, we might change the filter behavior so this isn't possible; but for the time being, I encourage you to design an interface in spite of your filter bonus!

Joined: 04/10/2015
Groups: Beta Folders
Just a thought maybe in

Just a thought maybe in future puzzle you can increase the bonus in the Core Existence: Complex for interaction and give more freedom with a lower requirement for Core Existence: Monomer.

Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons