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1090: 80 Residue Symmetric Dimer Design
Status: Closed


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bkoep's picture
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Joined: 11/15/2012
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Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 22 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 50 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Joined: 09/24/2012
Groups: Go Science

I've a solution with all bonus ok including core existence complex BUT my 2 monomers are still far away from each other ...

Joined: 10/30/2012
Groups: Beta Folders
me too

me too

bkoep's picture
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Joined: 11/15/2012
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Thanks for the feedback!

This came up in Puzzle 1068, as well:

If your monomer units are especially well-packed, it is possible to pass the "Core Existence: Complex" filter without designing an interface. We've intentionally set a low threshold here to allow more diversity in designs.

At some point, we might change the filter behavior so this isn't possible; but for the time being, I encourage you to design an interface in spite of your filter bonus!

Joined: 04/10/2015
Groups: Beta Folders
Just a thought maybe in

Just a thought maybe in future puzzle you can increase the bonus in the Core Existence: Complex for interaction and give more freedom with a lower requirement for Core Existence: Monomer.

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