puzzle picture
1076: Vancomycin Binder Design
Status: Closed

Summary

Name: 1076: Vancomycin Binder Design
Status: Closed
Created: 04/16/2015
Points: 100
Expired: 04/23/2015 - 23:00
Difficulty: Intermediate
Description: Design a binding pocket for vancomycin! Scientists in the Baker Lab are trying to design proteins that can bind vancomycin and upon binding generate a signal. With this technology it would be possible to test patients that have been treated with antibiotics if they still have small amounts left before they leave e.g. a hospital. The aim of this puzzle is to optimize the interaction between a protein and the small molecule vancomycin. This puzzle has four different starting structures, all with slightly different residues at the binding site; resetting the puzzle will cycle through the different models.
Categories: Design, Overall

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons