puzzle picture
1075: 75 Residue Monomer Design: More Sheets!
Status: Closed


Name: 1075: 75 Residue Monomer Design: More Sheets!
Status: Closed
Created: 04/13/2015
Points: 100
Expired: 04/20/2015 - 23:00
Difficulty: Intermediate
Description: In this puzzle, we're asking players to design a protein with no cysteine residues, and extra beta sheets! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

1Go Science10,361100
2Anthropic Dreams10,32284
3Beta Folders10,24970
4Void Crushers10,22357

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Top Soloists

1zeroblue 68 1821 Go Science10,328100
2MurloW 68 1821 Anthropic Dreams10,27898
3eusair 68 134  10,25696
4Madde 68 1821 Void Crushers10,22394
5mirp 35 83 Go Science10,19392

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bkoep's picture
User offline. Last seen 5 hours 2 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that at least 50% of residues are in sheets; penalties are incurred if fewer than 50% of residues form sheets.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.

Joined: 10/30/2012
Groups: Beta Folders


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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons