1073: Marburg Binder Design with Disulfides
|Name:||1073: Marburg Binder Design with Disulfides|
|Expired:||04/16/2015 - 23:00|
|Description:||Marburgvirus is a close relative of ebolavirus, and is similarly prone to epidemics in humans and primates. This is a design puzzle with 37 residues, near the interface of a target glycoprotein from the Marburg virus. At the binding site of the Marburg protein, there is already a beta hairpin derived from a human antibody. Build a scaffold around the starting design that will fold up properly and stabilize the binding hairpin! There are strong constraints to keep the hairpin residues in place, and you may not mutate residues at the interface. Players will receive an (extremely) large bonus for making up to 2 disulfide bonds. Remember to share your favorite designs using the Share with Scientist tool, even if those are not your best-scoring solutions!|
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